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Engineering next-generation RNA therapeutics inspired by extracellular vesicles
Our Mission
Our Mission
The Jauliac Lab investigates how extracellular vesicles and regulatory RNAs control the molecular networks that drive aggressive cancers.
By combining cancer biology, functional genomics and preclinical models, we aim to identify new therapeutic vulnerabilities and develop innovative multi-target RNA-based strategies, with a particular focus on triple-negative breast and pancreatic cancers.
Our research is organized around three complementary and interconnected areas.
Extracellular Vesicles
Extracellular Vesicles
We investigate how NFAT3-regulated extracellular vesicles carry regulatory RNAs and exert anti-tumor effects in aggressive cancers.
Combinatorial RNA therapeutics
Combinatorial RNA therapeutics
We develop defined combinations of RNA designed to modulate multiple cancer-driving pathways simultaneously.
Cancer Vulnerabilities
Cancer Vulnerabilities
We identify and characterize emerging molecular vulnerabilities in triple-negative breast and pancreatic cancers.
Featured Research
From scientific discovery to peer-reviewed publication (March 2025-July 2026)
A combinatorial RNA therapeutic strategy inspired by extracellular vesicles
A combinatorial RNA therapeutic strategy inspired by extracellular vesicles
Published in Molecular Therapy, a Cell Press journal
Our recent study published in Molecular Therapy demonstrates that a defined combination of 15 microRNAs reproduces the anti-tumoral activity of NFAT3-regulated extracellular vesicles.
This work establishes EV-inspired combinatorial RNA therapeutics as a new strategy to target multiple cancer-driving pathways simultaneously.
Featured publication
Tossou et al.
Molecular Therapy (2026), 2026 Jul 30:S1525-0016(26)00673-8. doi: 10.1016/j.ymthe.2026.07.052.
A combinatorial EVs-miRNA signature mediates the anti-tumoral activity of NFAT3-regulated extracellular vesicles in aggressive cancers
SFTCG Annual Meeting 2025
Conference presentation (preliminary results)
Enhancing anti-tumoral properties of specific extracellular vesicles via miRNA loading: A novel approach for gene therapy in breast and pancreatic cancer models
Presented by Guénolé Tossou
🏆 Best Oral Presentation Award, March 2025
From Discovery to Translation
Latest News
Publication in Molecular Therapy
Publication in Molecular Therapy
A new milestone in extracellular vesicle-inspired RNA therapeutics
Our recent publication in Molecular Therapy reveals how NFAT3-regulated extracellular vesicles mediate anti-tumoral effects through a defined combinatorial RNA signature.
RNA Therapeutics
RNA Therapeutics
Advancing combinatorial RNA-based strategies
Our research explores how combinations of regulatory RNAs can modulate complex cancer networks and provide new therapeutic perspectives for aggressive cancers.
Cancer Vulnerabilities
Cancer Vulnerabilities
Understanding cancer vulnerabilities
We investigate molecular mechanisms driving aggressive cancers to identify new opportunities for therapeutic intervention.
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